Autologous Conditioned Serum – Orthokine

Orthokine is also known as Autologous Conditioned Serum (ACS). It was developed after researchers found higher levels of destructive inflammatory cytokines (interleukin 1) in the joints of patients with osteoarthritis compared with patients with normal joints. Orthokine produces high concentrations of interleukin 1 receptor antagonists which changes the destructive environment inside the damaged joint. Extensive research has been done that found that 70% of patients with arthritis could expect a 50% or greater reduction in their joint pain lasting for 2-4 years (Level 1 evidence). Orthokine is also being used for successful treatment of soft tissue injuries like plantar fasciitis, Achilles tendinitis and muscle tears.

Orthokine is produced by:

1. Blood collection into special syringes that contain glass beads
2. Blood is incubated in the syringes for 6-24 hours at 37 C. When white blood cells come into contact with the glass beads it produces high concentrations of ant-inflammatory protective proteins (interleukin 1 receptor antagonists) plus additional growth factors.
3. Conditioned serum is then centrifuged and extracted under sterile conditions
4. Serum is divided up into usually 4-6 syringes at frozen at -20 C.
5. Patient is prepped and serum is thawed and injected using sterile technique into the joint or site of injury (ultrasounded guided if necessary)
6. Injection ideally performed once a week (x 4- 6)

Conditions treated:

• Osteoarthritis
• Plantar fasciitis
• Tendonitis & other soft tissue injuries

The treatment plan for all injuries is to treat cause and remove mechanical load from an injury if possible. Most injuries will respond to conservative treatment. If this treatment fails or is slow then PRP or ACS may be considered if appropriate for the patient.

The clinic specialises in safe delivery of injections. The clinic uses techniques that make most injections comfortable or tolerable.